COMBATING SARCOPENIA AND REDRAFTING THE NARRATIVE OF THE MUSCLE

Sarcopenia patients need to pay extra attention to the health of their muscles because it affects every aspect of their life.

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“Exercise along with high-quality, protein-rich meals has been shown to increase muscle mass, strength, and function.”

Hormone replacement therapies like Testosterone replacement therapy and Selective estrogen receptor modulators aid in the maintenance of skeletal muscle mass and function with the regeneration of damaged muscles.2

Other regenerative medicines like protein PGC-1A, PDE inhibitors, and metformin look promising including genetically altering genes to tackle sarcopenia.3

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Protein or amino acid supplements may maintain muscle protein synthesis and stop the loss of muscle caused by inactivity.1

Exercise and nutrition intervention are definitive objectives for the sustainable improvement of aging muscles. These strategies not only aid in alleviating muscular atrophy disorders like sarcopenia but also assist in preventing various health problems like lowering the incidence of Type 2 Diabetes and CVD.

Exercises: It boosts cellular integrity, enhances mitochondrial function, and increases muscle vascularity this helps the body to adjust to stress readily.

Exercise promotes the production of myokines, which control the development, differentiation, and proliferation of muscle cells and ultimately enhance muscular mass.4

Nutrition: Sarcopenia can be treated with high doses of vitamin D, antioxidant nutrients, and long-chain polyunsaturated fatty acids, which can increase muscle strength.
Protein Supplements: Leucine-enriched balanced amino acids and food supplements such as whey protein or creatine when the diet isn’t providing enough energy or protein.1

Ca HMB

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CaHMB is an astounding formulation designed with HMB, a bioactive metabolite which is one of the most promising dietary supplements for improving the functionality and muscle quality in old age. It is fortified with sunshine vitamin, cholecalciferol.

HMB (beta-hydroxy-beta-methylbutyrate) is a leucine metabolite with a protein anabolic effect. It is produced by the breakdown of the important branched-chain amino acid leucine. Leucine functions as a signaling molecule that promotes protein synthesis, giving it a well-known anabolic role in muscle.

HMB is thought to be the most significant regulator of muscle protein anabolism and plays a crucial nutritional role.

  • It has the capacity to activate the mechanistic Target of Rapamycin (mTOR) signaling pathway, which boosts protein synthesis.
  • It also inhibits the proteasome pathway, which induces muscle protein catabolism.

“Daily HMB supplementation (usually 3 g/day) has been demonstrated to increase muscle mass, reduce muscle injury, enhance protein synthesis, and attenuate proteolysis in older adults.” 5

It enhanced Lean Body Mass in supplemented older individuals in a subsequent year-long trial by Baier et al.

In the same study it was found muscle strength was found to be significantly reliant on the levels of vitamin D in circulation.

It is widely accepted that low levels of vitamin D are a separate risk factor for falls, poor physical performance, and rapid muscle loss.” 6

Final Thoughts

Though maintenance of muscle strength, quality, and function can still be achieved through resistance exercise training and proper diet, calcium form of HMB and vitamin D3 supplements may offer a special protective benefit for older adults who are unable or unwilling to exercise.

As the cornerstones of sarcopenia treatment, nutrition and exercise are important factors to take into account, say specialists. Though pharmaceutical drugs are developed that target various biological processes to address sarcopenia, tailored exercise, and proper nutrition continue to be the golden standard for therapy.

REFERENCES

  1. Front Med (Lausanne). 2021; 8: 739251.
  2. Sci Rep. 2020; 10: 19551.
  3. Antioxidants (Basel). 2023 Jan; 12(1): 44.
  4. Int J Environ Res Public Health. 2022 Jun; 19(12): 7232.
  5. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):529-541.
  6. J Gerontol A Biol Sci Med Sci. 2020 Nov; 75(11): 2089–2097.

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