Diseases of the musculoskeletal system affect 70% of the population over the age of 50 years.
Musculoskeletal diseases such as rheumatoid arthritis and polymyositis are characterized by chronic inflammation which is associated with the release of prostaglandins.
- Works by inhibiting the production of prostaglandins that cause inflammation and pain in the body.
- Epidemiological studies have revealed the reduced risk of several cancer types and neurodegenerative diseases by prolonged use of NSAIDs.
- Diclofenac Sodium (NSAIDs)
- A phenylacetic acid derivative, non-selective NSAID hence, inhibits the production of both physiologic and inflammatory prostaglandins.
- Highly effective at therapeutic doses in the treatment of pain and physical disability in rheumatic diseases.
- Diclofenac is useful for short-term treatment of postoperative pain, acute musculoskeletal pain, and dysmenorrhea.
- Paracetamol (Analgesics and antipyretics)
- Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor with weak anti-inflammatory effects.
- Superior overall gastrointestinal safety profile compared with NSAIDs.
- Demonstrated therapeutic efficacy in both acute and chronic pain.
- Paracetamol is active as a single agent and is additive or synergistic with NSAIDs and opioids, improving their efficacy and safety.
- A combination of paracetamol and an NSAID like Diclofenac Sodium may offer superior analgesic efficacy for treating acute postoperative pain compared with either drug alone.