Description

Gabapentin – Anti-epileptic drug.

• Used as an adjuvant in partial and secondarily generalised tonic-clonic seizures.

• Gabapentin and tricyclic antidepressants are efficacious in the treatment of painful diabetic neuropathy and postherpetic neuralgia.

• Approved for add-on therapy of focal seizures; increasingly used for the treatment of neuropathic pain.

Nortriptyline – Nortriptyline is a tricyclic antidepressant.

• Nortriptyline therapy may provide dual value for Parkinson’s Disease patients; 
• it can both treat depressive symptoms and 
• reduce alpha-synuclein accumulation, which may impact disease progression.

• Significantly reduces the accumulation of pathological α-synuclein which may impact disease progression.

Methylcobalamin 

• An active form of vitamin B12 is required for the integrity of myelin, neuronal function, proper red blood cell formation, and DNA synthesis.

• Helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promotes neurons to function properly.

COMBINATION:

Treating Diabetic Neuropathic Pain

• To decrease pain in patients suffering from diabetic neuropathy combined therapy with Gabapentin and Methylcobalamin can be more efficacious as compared to treatment with gabapentin alone. 

• This combination is safe with minimal side effects.

Superior analgesic effect in painful neuropathic condition

• Combination therapy of gabapentin and nortriptyline offers a pivotal modality in the management of uncontrolled neuropathic pain.