ZIVALIO-10 Tablets

A Blockbuster Anti-Diabetic Drug

 

COMPOSITION: Dapagliflozin 10 mg

  • A selective inhibitor of sodium-glucose co-transporter 2 (SGLT2).
  • Improves hyperglycemia and facilitates weight loss in type-2 diabetic patients.
  • Inhibits renal glucose re-absorption through SGLT2.
  • Prolong half-life and produces consistent  pharmacodynamic activity.
  • Induces steady rates of glucosuria.
  • Exhibits a diuretic effect.
  • Reduces the risk of cardiovascular death or HHF (Hospitalization for heart failure) by 17%.

INDICATIONS:

  • Type-II Diabetes Mellitus
  • Heart Failure

Dapagliflozin

  • Drug class: Sodium-glucose co-transporter 2 (SGLT2) inhibitors
  • Selective SGLT, inhibitor approved to improve glycemic control in type 2 diabetes.
  • Lowers blood glucose independent of insulin secretion and action by inhibiting renal reabsorption of glucose.
  • Its treatment is associated with weight reduction and has a low propensity to cause hypoglycemia. 
  • Treatment with Dapagliflozin significantly improved glycemic control and reduced body weight without reducing muscle mass in T2 DM patients. 
  • In a study involving 54 patients with uncontrolled T2 DM with a mean glycosylated hemoglobin HBA1C of 8.1% and treatment given was added on Dapagliflozin and non – SGLT2 inhibitor medicine for each group HBA1C was significantly decreased in both groups.