ACORD-PLUS (Atenolol 50mg + Hydrochlorothiazide 12.5mg + Losartan Potassium 50mg) Tablets: Uses, MOA, Benefits, and Recommended Dosage

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ACORD-PLUS Tablets: Uses, Benefits, Dosage and MoA


ACORD-PLUS tablets combine three active ingredients – Atenolol, Hydrochlorothiazide, and Losartan Potassium – to provide comprehensive management of hypertension and related cardiovascular conditions. This article explores the uses, mechanism of action (MOA), benefits, recommended dosage, and potential adverse reactions and precautions associated with ACORD-PLUS tablets.

Mechanism of Action (MOA):

Each component of ACORD-PLUS tablets works synergistically to lower blood pressure and reduce the workload on the heart:

  • Atenolol is a beta-blocker that blocks the action of adrenaline on the heart and blood vessels, resulting in decreased heart rate and blood pressure.
  • Hydrochlorothiazide is a diuretic that increases the excretion of sodium and water by the kidneys, leading to reduced blood volume and lower blood pressure.
  • Losartan Potassium is an angiotensin II receptor blocker (ARB) that relaxes blood vessels, allowing blood to flow more easily and reducing blood pressure.


ACORD-PLUS tablets are primarily prescribed for the treatment of hypertension (high blood pressure) and may also be indicated for the management of other cardiovascular conditions, such as heart failure and certain types of heart rhythm disorders.


The combination of Atenolol, Hydrochlorothiazide, and Losartan Potassium in ACORD-PLUS tablets offers several benefits:

  • Effective reduction of blood pressure levels.
  • Prevention of complications associated with hypertension, such as heart attack, stroke, and kidney damage.
  • Simplified medication regimen by combining three agents into a single tablet.
  • Potential improvement in overall cardiovascular health and quality of life.

Recommended Dosage:

The recommended dosage of ACORD-PLUS tablets should be individualized based on the patient’s medical history, current blood pressure levels, and response to treatment. Generally, one tablet is taken orally once daily, preferably in the morning with or without food. Healthcare providers may adjust the dosage as needed to achieve optimal blood pressure control while minimizing side effects.

Adverse Reactions and Precautions:

While ACORD-PLUS tablets are generally well-tolerated, they may cause certain adverse reactions, including dizziness, fatigue, headache, dry mouth, and electrolyte imbalances. Patients should be monitored for signs of hypotension, electrolyte abnormalities, and kidney function changes. ACORD-PLUS tablets are not recommended during pregnancy or breastfeeding and should be used with caution in patients with impaired renal function, hepatic impairment, or diabetes.


ACORD-PLUS tablets offer a comprehensive approach to managing hypertension and improving cardiovascular health. By combining three active ingredients with complementary mechanisms of action, they provide effective blood pressure control and reduce the risk of cardiovascular complications. However, patients should always follow their healthcare provider’s guidance and adhere to the prescribed dosage regimen.

Related Combinations:

Explore other cardiovascular medications and combination therapies offered by Invision Medi Sciences to address various aspects of heart health and hypertension management.

ACORD-PLUS: Comprehensive Hypertension Management for a Healthy Heart


What are the main uses of ACORD-PLUS tablets?

ACORD-PLUS tablets are primarily used to treat hypertension (high blood pressure) and can also help manage related cardiovascular conditions like heart failure and certain heart rhythm disorders.

How do ACORD-PLUS tablets work to lower blood pressure?

ACORD-PLUS tablets contain a combination of Atenolol, Hydrochlorothiazide, and Losartan Potassium. Atenolol slows the heart rate, Hydrochlorothiazide reduces blood volume by increasing urine output, and Losartan Potassium relaxes blood vessels, all working together to lower blood pressure.

What is the recommended dosage for ACORD-PLUS tablets?

The recommended dosage of ACORD-PLUS tablets is typically one tablet taken orally once daily. However, the dosage may vary depending on individual patient factors, so it’s important to follow the instructions provided by your healthcare provider.

What are the potential side effects of ACORD-PLUS tablets?

Common side effects of ACORD-PLUS tablets may include dizziness, fatigue, headache, dry mouth, and electrolyte imbalances. Serious side effects are rare but may include hypotension, kidney problems, or allergic reactions. Consult your doctor if you experience any unusual symptoms.

Can ACORD-PLUS tablets be taken during pregnancy or breastfeeding?

ACORD-PLUS tablets are generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus or newborn. Pregnant or breastfeeding individuals should consult their healthcare provider for alternative treatment options.

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