PRODUCT SYNOPSIS
Ca HMB is an astounding formulation designed with HMB, a bioactive metabolite that is one of the most promising dietary supplements for improving functionality and muscle quality in old age. It is fortified with sunshine vitamin, cholecalciferol.
COMPOSITION & BENEFITS
Ca HMBTM (HMB [from Calcium B-Hydroxy ẞ-Methyl butyrate Monohydrate) 3000 mg + VITASHINE (As Vegan Vitamin D3] 15 mcg)
HMB and vitamin D3 may provide protective benefits for older adults who are unable or unwilling to exercise. CaHMB is a key regulator of muscle protein anabolism, it boosts fat-free muscle mass and enhances protein turnover in humans. Fortified with vitamin D supports HMB in maximizing muscle strength and function. 1
In senior patients, it improved wound healing, shortened their periods of immobility, and increased muscle strength without affecting their body mass index. Additionally, it lessened bed rest and the associated issues following an orthopedic procedure.2
MECHANISM AND PHARMACOLOGICAL ACTIONS
According to the literature that is currently available, HMB’s mode of action in the body is primarily dependent on its capacity to decrease the effectiveness of intracellular proteolytic pathways and increase the integrity of the myocyte cell membrane, or sarcolemma (Asadi et al., 2017; Nissen and Abumrad, 1997; Wilson et al., 2008).4
Supplementing with HMB has been shown to have ergogenic effects by improving the integrity of the sarcolemma (cell membrane surrounding a skeletal muscle fiber), inhibiting the ubiquitin pathway, decreasing cell apoptosis, increasing protein synthesis (mTOR pathway), stimulating the GH/IGF-1 axis, and promoting the proliferation and differentiation of muscle stem cells. 3
It stimulates and counteracts the suppression of protein synthesis brought on by a variety of catabolic agents, including proteolysis-inducing factors. 4
INDICATIONS
- Sarcopenia
- Athletic performances
- Muscle loss in HIV/AIDS and Cancer patient
- Cachexia (metabolic syndrome with marked weight loss & muscle loss commonly seen in people with advanced cancer)
- Postsurgical Recovery
ROUTE OF ADMINISTRATION
Oral
DOSAGE
Three film-coated tablets per day or as directed by a physician
POSSIBLE SIDE / ADVERSE EFFECTS
HMB seems to be usually safe and well tolerated with few to no known adverse effects
CONCLUSION
CaHMB which is a combination of Calcium and Vitamin D3 may provide protective benefits for older adults who are unable or unwilling to exercise. Nutrition and exercise are crucial for sarcopenia treatment, with tailored exercise and proper nutrition being the golden standard.
REFERENCES
1. Journal of Parenteral and Enteral Nutrition / Vol. 35, No. 6, November 201
2. Nutr Clin Pract. 2016 Dec;31(6):829-835.
3. J.R. Stout et al. / Experimental Gerontology 48 (2013) 1303–1310
4. J Hum Kinet. 2019 Aug; 68: 211–222.
FAQs
What is HMB’s biochemistry ?
The HMB is a metabolite of leucine which is one of the three essential branched-chain amino acids (BCAAs) along with valine and isoleucine. The metabolic routes of these amino acids are similar. Leucine functions as a signaling molecule that promotes protein synthesis, giving it a well-known anabolic role in muscle.
What is the full form of HMB ?
Beta-hydroxy-beta-methylbutyrate (HMB).
Is Calcium HMB a form of calcium ?
Ca HMB is not a form of calcium, but a metabolite of leucine. Calcium HMB is a compound combining HMB molecules with calcium to enhance absorption. This substance is a good source of HMB and calcium and is frequently taken as a dietary supplement.
Is HMB a steroid ?
No, HMB is not a steroid or performance-enhancing drug. It is a leucine metabolite with a protein anabolic effect. HMB is categorized as a dietary supplement.
Does CaHMB cause liver damage ?
HMB decreases proteolysis in muscles; and may affect not only muscle protein balance but also the repair of the injured liver. Its supplementation in humans is safe and may decrease cardiovascular risk factors.5
Can HMB be consumed on an empty stomach ?
HMB can be ingested on an empty stomach or with a meal.
How effective is CaHMB ?
Systematic review and meta-analysis found that HMB supplementation during resistance exercise training may cause a slight weight increase but does not significantly enhance free fat mass gains or losses.
How long CaHMB can be used?
Safe usage has been demonstrated at doses up to 3 grams per day for up to a year.
