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FENTISOFT – Fenticonazole Nitrate 600 mg Capsules

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PRODUCT SYNOPSIS

FentiSoft – 600TM is an antifungal champion formulated with 600 mg of fenticonazole. It is a new imidazole derivative, recommended for the management of symptomatic vulvovaginal infections including vulvovaginal candidiasis. It is a potent azole compound, documented to have fungicidal yet broad spectrum activity against dermatophytes, yeasts, Protozoa, and Bacterial sp.

SPECTRUM OF ACTIVITY

Fenticonazole has demonstrated strong antifungal properties against gram-positive microorganisms in vitro, with dermatophytes, yeasts, and dimorphic fungi in clinical studies.

PHARMACOLOGICAL ACTION

Fenticonazole exhibits a distinct anti-mycotic mechanism of action through three mechanisms:

(i) It inhibits Candida growth by blocking secretory aspartate protease.

(i) Cytoplasmic membrane damage; disrupts fungal sterol synthesis by targeting cytochrome P450 enzyme (hemoproteins).

(iii) Exerts antioxidant effects by altering fungal cell structure and function. It weakens the fungus by inhibiting cytochrome oxidases and peroxidases and eliminates the infection. 5

BENEFITS

  1. It is effective in treating superficial fungal and vaginal infections, with high cure rates and low relapse rates. 5
  2. Fenticonazole may be the best topical option as an alternative to multi-agent therapy when treating mixed infections containing mycotic, bacterial, dermatophyte, and/or Trichomonas species.                    
  3. It is fast-acting; after starting treatment, clinical efficacy is usually seen in a few days.6
  4. A 600 mg dose of fenticonazole in ovules significantly reduced 90% of vaginal yeast infections in women as per study reports.7

INDICATIONS

  • Vaginal candidosis, vulvovaginal candidiasis, and candidal vulvovaginitis
  • Bacterial vaginosis
  • Trichomoniasis

SIDE/ ADVERSE EFFECTS

Although they are rare, side effects from fenticonazole could include some skin irritation or itching; it is temporary and goes away quickly most of the time. Furthermore, long-term use of fenticonazole may cause an allergy to develop in a few people.

RECOMMENDED DOSAGE

One applicator full, 600 mg as a single dose or as recommended by a healthcare professional. Use this medication exactly as prescribed by your physician at all times. Never take more medication than is recommended.

ROUTE OF ADMINISTRATION/ APPLICATION

Inserted into the vagina using an applicator usually at night before going to bed.

CONCLUDING REMARKS

FentiSoft – 600TM, a potent antifungal and antibacterial medication, exhibits exceptional efficacy in treating vaginal infections. With a documented success rate of around 90%, reducing symptoms and eliminating causative yeast, Fenticonazole stands as a rapid and effective choice for vaginal yeast infections. Approved by CFDA (China Food and Drug Administration), it is considered a promising therapeutic option with its broad spectrum that can target fungi, bacteria, and protozoa.

For effective treatment of vaginal infections, consider Fentisoft and seek professional guidance before allowing discomfort to persist.

REFERENCES

1.	Tempera, G. (2005). Vaginal infections: epidemiology and risk factors. 
2.	Singapore Med J. 2020 Jun; 61(6): 297–301. 
3.	International Journal of STD & AIDS 2011; 22: 421–429
4.	Arzneimittelforschung.1981;31(12):2133-7.
5.	Nanavati, et al.: Int. J. Sci. Study | Aug 2017 | Vol 5 | Iss 5
6.	Drugs 68, 2183–2194 (2008). 
7.	J Int Med Res. 1989 Jul-Aug;17(4):369-72.
8.	Pharmacol Res. 2021 Nov:173:105860.

FAQs

How is Fentisoft vaginal capsule used?

Fentisoft vaginal capsule is inserted into the vagina with a special applicator. Unwrap the suppository and place it in the applicator. Gently insert the applicator tip high in the vagina and push the plunger to release. 

Can I urinate after capsule insertion?

It is advised to wait at least 20-30 minutes after putting in the vaginal capsule before urinating. See your healthcare practitioner if you are uncomfortable or have any concerns.

Can you use Fentisoft while you are on periods?

During periods it will not be effective. You should wait till your menstruation is over. The suppository might come out undissolved with blood due to bleeding. Also, it is advised not to have sex until you have finished your treatment.

How long does Fentisoft vaginal capsule take to work?

For fungal skin infections, the duration of treatment as well as the dosage varies according to condition.

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