Paracetamol administered via the oral route has a slower onset of analgesia (approximately 45 minutes) when compared with the IV route (20 minutes), but thereafter the clinical effect is similar.
- When the oral route of administration is not possible or rapid analgesia is needed, IV administration is the route of choice.
- Study shows that i.v. acetaminophen in a single 1,000-mg dose is safe and effective in reducing fever.
Paracetamol 300 mg (Immediate Release) + Paracetamol 700 mg (Sustaned Release) 1000mg
- Shows the property of effective analgesics across a variety of surgical procedures.
- Fastens recovery after surgery and ensures rehabilitation and transfer to the outpatient setting, while reducing overall costs.
- Enhances bioavailability and earlier onset of analgesic effect in the immediate postoperative period.
- FDA-approved drug used for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.
- Advantage of paracetamol over other analgesic agents used for the treatment of postoperative pain is its safety and tolerability profile.
- Generates a faster onset of action and results in more predictable pharmacokinetics than oral formulation.
- Produces antipyresis by inhibiting the hypothalamic heat-regulating center.
- Exhibits anti-inflammatory activity which is related to inhibition of prostaglandin synthesis in the CNS.