- Drug class: Triaminopyridines
- Flupirtine is a centrally acting analgesic non-opioid drug without antipyretic & anti-inflammatory properties is of choice in acute & chronic pain, especially of musculoskeletal origin.
- Clinical use of flupirtine will be more acceptable as it lacks the typical side effects of the opioid drugs.
- Approved by European Medicine Agencies, at recommended clinical doses, produces muscle-relaxing effects in the presence of abnormally increased muscle tension.
- Has neuroprotective properties and possesses a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties (reduce neuropathic pain). (Yadav et al )
- Flupitrine being a K+ channel opener increases the pain threshold of pain sensation.
- Drug class: Aniline analgesic
- One of the oldest & most used analgesics and antipyretic drugs.
- Mediated centrally and may involve direct and indirect inhibition of central cyclooxygenases, but also the activation of the endocannabinoid system and spinal serotonergic pathway.
- The central analgesic action of paracetamol is like that of aspirin.
- It raises the pain threshold but has weak peripheral anti-inflammatory action.