Description

Flupirtine 

• Drug class: Triaminopyridines
• Flupirtine is a centrally acting analgesic non-opioid drug without antipyretic & anti-inflammatory properties is of choice in acute & chronic pain, especially of musculoskeletal origin. 
• Clinical use of flupirtine will be more acceptable as it lacks the typical side effects of the opioid drugs.
• Approved by European Medicine Agencies, at recommended clinical doses, produces muscle-relaxing effects in the presence of abnormally increased muscle tension. 
• Has neuroprotective properties and possesses a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties (reduce neuropathic pain). (Yadav et al ) 
• Flupitrine being a K+ channel opener increases the pain threshold of pain sensation. 

Paracetamol

• Drug class: Aniline analgesic

• One of the oldest & most used analgesics and antipyretic drugs.

• Mediated centrally and may involve direct and indirect inhibition of central cyclooxygenases, but also the activation of the endocannabinoid system and spinal serotonergic pathway. 

• The central analgesic action of paracetamol is like that of aspirin. 

• It raises the pain threshold but has weak peripheral anti-inflammatory action.