Description

Fexofenadine

Drug class: Antihistamines

• Nonanticholinergic, a highly selective second-generation antihistamine, available for oral treatment of allergic rhinitis and chronic urticaria.

• Is non-sedating due to decreased blood-brain barrier permeability, and is devoid of cardiovascular side effects.

• Relieves the ocular symptoms of allergic conjunctivitis, which occur concomitantly with AR, was significantly better than loratadine in improving quality of life.

Montelukast

Drug Class: Leukotriene receptor antagonist

• Montelukast is a systemically active drug with a targeted, dual mechanism of action, acting both as a bronchodilator and anti-inflammatory.

• This potent leukotriene receptor antagonist reduces the signs and symptoms of chronic asthma in adults and children. 

• Montelukast may be worth trying for patients with chronic idiopathic urticaria when the condition is not sufficiently controlled with histamine H(1)-receptor antagonists.

COMBINATION:

• A study found that montelukast-fexofenadine showed significantly better control of AR symptoms as compared to groups using antihistaminic alone or with placebo.

• The mean change in total nasal symptom score was significant in the montelukastfexofenadine group as compared to the montelukastlevocetirizine group.

• The additional anti-inflammatory effect of fexofenadine and bronchodilator effect of montelukast might be the reason for this change.

• Combination therapy of fexofenadine – montelukast was effective for patients with conventional therapy-resistant prurigo nodularis and pemphigoid nodularis (skin disorder) without side effects.