PULMOLIFE-PF 200 Tablets

MULTI-FUNCTIONAL ANTI-FIBRINOLYTIC WITH ANTI-INFLAMMATORY ACTION

Pirfenidone 

Drug class: Pyridones

  • Pirfenidone is an orally administered, excellent antifibrotic agent and anti-inflammatory agent, that diminishes accumulated inflammatory cells and cytokines in the lungs. 
  • Beneficial in the treatment of idiopathic pulmonary fibrosis, progressive fibrotic interstitial lung diseases (ILDs), fibrotic non-specific interstitial pneumonia, and chronic hypersensitivity pneumonitis.
  • It is an effective inhibitor of fibroblast, myometrial, and leiomyoma cell proliferation.
  • Demonstrates reduced lung function decline decreases mortality and improves progression-free survival.
  • Modulates fibrogenic growth factors, myofibroblast differentiation, collagen and fibronectin synthesis, and deposition of extracellular matrix.
  • Possess a well-characterized long-term safety and tolerability profile.
  • Inhibit apoptosis, downregulate ACE receptors expression, decrease inflammation by several mechanisms and ameliorates oxidative stress and hence protect pneumocytes.