Description

Ambroxol

Drug class: Mucolytic agent

• A mucolytic agent that increases bronchial secretion and reduces the viscosity of tenacious sputum and expedites the removal of it by coughing. 

• Ambroxol hydrochloride also upturns the clearance of mucociliary secretions.

Levosalbutamol

Drug class: Beta agonist

• Levosalbutamol is a therapeutically active isomer and has all the beta 2 agonist activity.

• Levosalbutamol interacts with B2 adrenoreceptors and has anti-edematous, bronchodilator and bronchoprotective properties and inhibits activation of eosinophils and mast cells. 

(Note: Eosinophils are allergic inflammatory sites and mast cells contribute to the airway inflammatory 

response)

• Levosalbutamol has approximately 100 and 2 times greater binding affinity for ẞ2 adrenergic receptor than S Salbutamol and racemic salbutamol respectively.”

Guaifenesin

Drug class – Expectorant

• Guaifenesin is an expectorant which increases the amount of output of bronchial secretions and sputum by reducing the viscosity of the secretions. 

• It reduces the surface tension and adhesiveness of sputum. 
• It increases the efficacy of cough reflex, ciliary actions and mucociliary removal for accumulated bronchial secretions from the lower and upper airway.

COMBINATION:

• Combination of Levosalbutamol, Ambroxol Hydrochloride and Guaifenesin was safe as well as efficacious for the treatment of productive cough.