THIONEX-A4 Capsules

 A Combination that Works like a Charm

COMPOSITION – Thiocolchicoside IP 4mg + Aceclofenac IP 100mg

Thiocolchicoside

  • Drug Class: Natural anti-inflammatory glycoside, Natural analgesic
  • A semi-synthetic derivative of colchicines, a natural glycoside originated from flower seeds of superba gloriosa.

(Note: GABA is a chemical messenger in your brain)  

  • Has GABA (gamma-aminobutyric acid) mediated action, so it shows both myo-relaxant (muscle relaxant) as well as analgesic activity.
  • Produces muscle relaxation without any subjective or objective sedative side-effects.

Aceclofenac is a non-steroidal anti-infammatory

drug (NSAID). Aceclofenac has higher anti-infammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the  action of a  substance in the body called  cyclooxygenase. Cyclooxygenase  is  involved  in  the  production  of  prostaglandin (chemical in the body) which causes pain, swelling and infammation [2]. A tablet  dosage from containing all the three, (ACE 50 mg, SERA 5  mg  and  PCM  250  mg),  is  commercially  available  in  the  market and  used  as  anti-infammatory,  analgesic  and  antipyretic  agents. ACE, SERA  and PCM are  oficially available in  IP. Literature  reviews revealed  that  UV Spectroscopy  method  have been  reported  for  the determination of ACE, SERA and PCM individually in ph

Aceclofenac 

  • Drug class: NSAID of BCS Class II
  • A NSAID that has higher anti-inflammatory action than conventional NSAIDs, also inhibits unfavourable cytokines.
  • Works by blocking the cyclooxygenase (COX) that releases prostaglandin (chemical in the body) which causes pain, swelling and inflammation in the body. 
  • Used as anti-inflammatory, analgesic and antipyretic agent, this beneficial Cox inhibitor has selectivity for Cox-2, and is well tolerated. 
  • Has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.

COMBINATION

  • Treating Low Back Pain with the combination of aceclofenac + thiocolchicoside, significantly reduced the intensity of pain and improved the mobility in 7 seven days without any side-effects.
  • Fixed Dosage Combination of thiocolchico & aceclofenac for Myofascial pain syndrome symptoms was slightly more effective and with far less side effects, compared to FDC of chlorzoxazone, aceclofenac and paracetamol.