COBANERVE – B12 : Methylcobalamin Nasal Spray

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A Promising Frontier for Amplified Treatment for Vitamin B12


Cobanerve-B12 is a nasal spray formulation designed to deliver Methylcobalamin (vitamin B12) through intranasal administration.


Methylcobalamin is an active synthetic form of vitamin B12, a B vitamin that is crucial for cellular metabolism, particularly for DNA synthesis, methylation, and mitochondrial metabolism.

Intranasal Administration of Nasal Cobanerve-B12 offers:

Enhanced Patient Compliance: Provides a sustained increase in baseline cobalamin concentrations, resulting in a steady increase in hemoglobin levels. Nasal vitamin B12 may be more effective in treating vitamin B12 deficiency in patients receiving metformin compared to oral methylcobalamin, according to studies.

Improved Absorption: Offers improved systemic absorption, avoidance of first-pass metabolism, and non-invasive delivery.

Reduced Discomfort: Easy administration and avoids drug complexation.

Cost-effective: Compared to intramuscular injections, intranasal administration of vitamin B12 appears to be a safe and effective option.

Safety: Intranasal application of vitamin B12 seems a safe and effective alternative to intramuscular injections. Minimizes potential for adverse systemic effects.


The active form of vitamin B12 Methylcobalamin, helps in the synthesis of methionine and S-adenosylmethionine. It is required for the integrity of myelin, neuronal function, proper red blood cell formation, and DNA synthesis. The methylcobalamin nasal spray increases bloodstream levels through hydroxocobalamin absorption and contributes to the overall pool of vitamin B12 in the body.

Vitamin B12 is involved in the metabolism of fat and carbohydrates and is necessary for the synthesis of DNA, the production of red blood cells, and neurological function.


  • Vitamin B12 Deficiency  due to malabsorption-related causes such as autoimmune gastritis (pernicious anemia), celiac disease, inflammatory bowel disease, surgical gastrectomy, gastric bypass, and ileal resection.
  • Vitamin B12 deficiency induced as a result of nutritional habits (strict vegans, breastfed infants born to vegan mothers with reduced dietary intake of animal products), drug interference (long-term metformin use).


Not recommended to use if you have cold or runny nose.


No severe side effects were reported. Sometimes mild, non-serious treatment-emergent adverse events like nasal congestion may occur, which are resolved without any treatment being required.


No significant drug interactions were recorded.


500 mcg/dose for 4 weeks or as prescribed by a healthcare professional.


While closing your mouth and taking a slow, deep breath in through your nose, it should be inhaled while simultaneously pressing the plunger firmly upward with your thumb.


Designed to overcome the shortcomings of the oral and intramuscular formulations of vitamin B12, Cobanerve-B12 is a reliable, painless, and easy-to-administer alternative to oral and parenteral formulations of vitamin B12. It conveniently and efficiently delivers methylcobalamin (vitamin B12) for an improved patient experience.

With its intranasal administration technique, it has revolutionized drug delivery. Any patient, regardless of condition, can self-administer it; this includes individuals with malabsorption, post-bariatric surgery, pernicious anemia, nausea, or vomiting. 


1) Journal of Diabetology 13(4):p 347-352, Oct–Dec 2022. 

3) Eur J Pediatr. 2020 Feb;179(2):349-352. 

2) Gastroenterology. 1997 Aug;113(2):430-3.

3) BMC Complement Altern Med. 2013; 13: 110.

4) Seth, T., et al. Int J Endocrinol Metab Disord, vol. 7, no. 1, 2021

5) Nutrients. 2020 Apr; 12(4): 1038.


Is vitamin B12 nasal spray effective?

Vitamin B12 nasal spray is shown to provide much superior absorption of vitamin B12 when compared with oral vitamin B12 and can be used as an effective alternative.

What is the purpose of vitamin B12 nasal spray?

To overcome the shortcomings of the oral and intramuscular formulations of vitamin B12, a nasal spray of methylcobalamin (active form of vitamin B12) has been formulated.

What is the ideal time to administer Cobanerve-B12 (Methylcobalamin Nasal spray)?

 Cobanerve-B12 (Methylcobalamin Nasal Spray) should be administered at least one hour before or one hour after ingestion of hot foods or liquids.

How often should you administer Vitamin B12 Nasal Spray?

For vitamin B12 deficiency and pernicious anemia in adults, it is recommended one spray once a week to one nostril. There are 500 micrograms (mcg) in each spray. Each spray contains 500 micrograms (mcg). Your doctor may adjust your dose as needed.

Is B12 Nasal Spray over the counter?

Cobanerve-B12 (Methylcobalamin Nasal spray) is not an OTC, it is a prescription medicine used as a supplement to treat vitamin B 12 deficiency.

Is Vitamin B12 spray safe to use at night?

If taking Vitamin B12 Nasal Spray at night is comfortable, by all means you can, but it advisable better off using the vitamin’s natural energy-boosting properties in the morning for best results.

Why is Vitamin B12 Nasal Spray better?

Vitamin B12 Nasal Spray better is better because it is non-invasive method, hence painless, and easy-to-administer and avoids over-reliance on the digestive system.   

Does Vitamin B12 Nasal Spray have any side effects?

It is generally safe with little or no side effects.

Is Methylcobalamin Nasal Spray a steroid?

Methylcobalamin Nasal Spray is not a steroid, but a form of vitamin B12 essential for red blood cell formation, neurological function, and DNA synthesis.

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