Sustained Release for Sustained Relief in Hyperacidity 

COMPOSITION: Esomeprazole Magnesium 40mg + Domperidone IP 20mg (SR) + Domperidone IP 10mg (IR)


An effective combination with complementary actions in the treatment of Gastroesophageal reflux disease (GERD) and controlling hypersecretory conditions.


Drug Class:  Proton pump inhibitors

  • It is the S-isomer of omeprazole and the first such inhibitor to be developed as a single isomer. 
  • It has higher metabolic stability, resulting in better and more consistent bioavailability compared with the racemate, omeprazole.
  • It is evident that esomeprazole is superior for symptom relief and healing in patients with erosive esophagitis Röhss et al.
  • Esomeprazole has been shown to provide good therapeutic effects, with clinical superiority to intragastric pH control and symptom relief. 
  • Several trials have demonstrated the safety and tolerability of esomeprazole in children and adolescents.


Drug Class:  Anti-emetic

  • Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist.
  • Domperidone is used as a prokinetic agent for the treatment of upper gastrointestinal motility disorders. 
  • It continues to be an attractive alternative to metoclopramide because of its fewer neurological side effects. 
  • On oral administration, it is rapidly absorbed from the stomach and the upper part of the gastrointestinal tract with few side effects reported.2 


  • Domperidone Sustained Release (SR)
  • The short biological half-life of the drug (7 h) also favors the development of a sustained release formulation.
  • Its SR achieves better therapeutic effects and improves patient compliance, maintaining consistent therapeutic concentration throughout the 24 h period.3
  • Domperidone Immediate Release (IR)
  • Immediate release plays the main role in successful therapeutic performance and makes a significant effect on the quick onset of action in oral administration.
  • Has rapid onset of action and supports sustained release activities.

Domperidone (SR + IR)

  • Unique gastrokinetic and antiemetic drug that speeds up gastrointestinal peristalsis.
  • Provides good relief of symptoms in patients with diabetic gastropathy.


  • Combination of domperidone and esomeprazole was more effective in improving the endoscopic reflux score in the treatment of gastroesophageal reflux in children with difficult-to-treat asthma.