Description

Clavid A 375: Amoxycillin 1000 mg + Clavulanic acid 200 mg

Clavid A 625: Amoxycillin 250 mg + Clavulanic acid 125 mg

Amoxycillin (penicillin-like antibiotics) + Clavulanic acid (beta-lactamase inhibitors)

• In clinical trials amoxicillin/clavulanic acid is clinically and bacteriologically superior to amoxicillin alone.

• Clavulanic acid is absorbed from the gut to an extent consistent with allowance for combination with amoxicillin as an oral drug. Brown et al (1976).

• Although clavulanic acid has only weak antibiotic properties, as a potent beta-lactamase inhibitor (like amoxicillin), it enhances the activity of beta-lactam antibiotics against many resistant Gram-positive and Gram-negative bacterial infections, Haginaka et al (1981).

• Synergistic effects were produced by amoxicillin with clavulanic acid against ampicillin-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Proteus Vulgaris, and Bacteroides fragilis.

• Combining clavulanic acid with amoxicillin does not alter significantly the pharmacologic parameters of either drug.