Fast Relief from Furious Coughs


Dextromethorphan I.P. 10 mg + Phenylephrine HBr I.P. 5mg + Chlorpheniramine Maleate I.P. 2 mg + Menthol I.P. 1 mg



Drug class – Antitussives

  • Dextromethorphan has been demonstrated to significantly suppress acute cough; highly significant reduction in cough counts with the dose of 30 mg dextromethorphan.
  • Found to be superior in the capsaicin challenge model; has a relatively slow onset of action peaking in efficacy after ∼2 hours.
  • Has a prolonged antitussive activity, being significantly better than placebo after as long as 24 hours.

Phenylephrine hydrobromide

Drug class – Nasal decongestant

  • A selective alpha-1 adrenergic receptor agonist used primarily as a decongestant in symptoms associated with cold.
  • Its effectiveness stems from its vasoconstriction of nasal blood vessels leading to decreased mucosal edema.

Chlorpheniramine maleate

Drug class – Antihistamines

  • Chlorpheniramine maleate is a first-generation antihistaminic that antagonizes histamine H1-receptor. 
  • It is specifically a potent inverse agonist of the histamine H1 receptor 
  • It is mainly used as an anti-allergic but has some anti-depressant and anti-anxiety actions, with unknown mechanism as well


Drug class – Counterirritant

  • Menthol is a monoterpene produced by the peppermint plant Mentha arvens.
  • Menthol’s cooling activity is through the specific ‘cold’ receptor TRPM8, a member of the transient receptor potential family of nociceptors, primarily located on afferent sensory neurons.
  • Evidence indicates that the antitussive activity of menthol may reside in the activation of nasal as opposed to lung sensory afferents.